Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype
Lope, Virginia; Guerrero-Zotano, Ángel; Casas, Ana; Baena-Cañada, José Manuel; Bermejo, Begoña; Pérez-Gómez, Beatriz; Criado-Navarro, Inmaculada; Antolín Novoa, Silvia; Sánchez-Rovira, Pedro; Ramos-Vázquez, Manuel; Antón, Antonio; Castelló, Adela; García-Saénz, José Ángel; Muñoz, Montserrat; de Juan, Ana; Andrés, Raquel; Llombart-Cussac, Antonio; Hernando, Blanca; Franquesa, Rosa María; Caballero, Rosalia; Priego-Capote, Feliciano; Martín, Miguel; Pollán, Marina
Identificadores
Identificadores
URI: http://hdl.handle.net/20.500.11940/16290
PMID: 33066483
DOI: 10.3390/nu12103132
ISSN: 2072-6643
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Fecha de publicación
2020Título de revista
Nutrients
Tipo de contenido
Journal Article
DeCS
estudios de casos y controles | estilo de vida | ácidos grasos | fosfolípidos | neoplasias de la mama | mediana edad | humanos | riesgo | adulto | conducta alimentariaMeSH
Risk | Adult | Breast Neoplasms | Middle Aged | Humans | Phospholipids | Case-Control Studies | Fatty Acids | Life StyleResumen
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-gamma-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.