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dc.contributor.authorLope, Virginia
dc.contributor.authorGuerrero-Zotano, Ángel
dc.contributor.authorCasas, Ana
dc.contributor.authorBaena-Cañada, José Manuel
dc.contributor.authorBermejo, Begoña
dc.contributor.authorPérez-Gómez, Beatriz
dc.contributor.authorCriado-Navarro, Inmaculada
dc.contributor.authorAntolín Novoa, Silvia 
dc.contributor.authorSánchez-Rovira, Pedro
dc.contributor.authorRamos-Vázquez, Manuel
dc.contributor.authorAntón, Antonio
dc.contributor.authorCastelló, Adela
dc.contributor.authorGarcía-Saénz, José Ángel
dc.contributor.authorMuñoz, Montserrat
dc.contributor.authorde Juan, Ana
dc.contributor.authorAndrés, Raquel
dc.contributor.authorLlombart-Cussac, Antonio
dc.contributor.authorHernando, Blanca
dc.contributor.authorFranquesa, Rosa María
dc.contributor.authorCaballero, Rosalia
dc.contributor.authorPriego-Capote, Feliciano
dc.contributor.authorMartín, Miguel
dc.contributor.authorPollán, Marina
dc.date.accessioned2022-03-17T08:18:00Z
dc.date.available2022-03-17T08:18:00Z
dc.date.issued2020
dc.identifier.issn2072-6643
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33066483es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16290
dc.description.abstractThis study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-gamma-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshRisk*
dc.subject.meshAdult*
dc.subject.meshBreast Neoplasms*
dc.subject.meshMiddle Aged*
dc.subject.meshHumans*
dc.subject.meshPhospholipids*
dc.subject.meshCase-Control Studies*
dc.subject.meshFatty Acids*
dc.subject.meshLife Style*
dc.titleSerum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtypeen
dc.typeJournal Articlees
dc.authorsophosLope, Virginia;Guerrero-Zotano, Ángel;Casas, Ana;Baena-Cañada, José Manuel;Bermejo, Begoña;Pérez-Gómez, Beatriz;Criado-Navarro, Inmaculada;Antolín, Silvia;Sánchez-Rovira, Pedro;Ramos-Vázquez, Manuel;Antón, Antonio;Castelló, Adela;García-Saénz, José Ángel;Muñoz, Montserrat;de Juan, Ana;Andrés, Raquel;Llombart-Cussac, Antonio;Hernando, Blanca;Franquesa, Rosa María;Caballero, Rosalia;Priego-Capote, Feliciano;Martín, Miguel;Pollán, Marina
dc.identifier.doi10.3390/nu12103132
dc.identifier.pmid33066483
dc.identifier.sophos36245
dc.issue.number10es
dc.journal.titleNutrientses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Oncoloxía médicaes
dc.rights.accessRightsopenAccess
dc.subject.decsestudios de casos y controles*
dc.subject.decsestilo de vida*
dc.subject.decsácidos grasos*
dc.subject.decsfosfolípidos*
dc.subject.decsneoplasias de la mama*
dc.subject.decsmediana edad*
dc.subject.decshumanos*
dc.subject.decsriesgo*
dc.subject.decsadulto*
dc.subject.decsconducta alimentaria*
dc.subject.keywordCHUACes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number12es


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Atribución 4.0 Internacional
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