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Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype
dc.contributor.author | Lope, Virginia | |
dc.contributor.author | Guerrero-Zotano, Ángel | |
dc.contributor.author | Casas, Ana | |
dc.contributor.author | Baena-Cañada, José Manuel | |
dc.contributor.author | Bermejo, Begoña | |
dc.contributor.author | Pérez-Gómez, Beatriz | |
dc.contributor.author | Criado-Navarro, Inmaculada | |
dc.contributor.author | Antolín Novoa, Silvia | |
dc.contributor.author | Sánchez-Rovira, Pedro | |
dc.contributor.author | Ramos-Vázquez, Manuel | |
dc.contributor.author | Antón, Antonio | |
dc.contributor.author | Castelló, Adela | |
dc.contributor.author | García-Saénz, José Ángel | |
dc.contributor.author | Muñoz, Montserrat | |
dc.contributor.author | de Juan, Ana | |
dc.contributor.author | Andrés, Raquel | |
dc.contributor.author | Llombart-Cussac, Antonio | |
dc.contributor.author | Hernando, Blanca | |
dc.contributor.author | Franquesa, Rosa María | |
dc.contributor.author | Caballero, Rosalia | |
dc.contributor.author | Priego-Capote, Feliciano | |
dc.contributor.author | Martín, Miguel | |
dc.contributor.author | Pollán, Marina | |
dc.date.accessioned | 2022-03-17T08:18:00Z | |
dc.date.available | 2022-03-17T08:18:00Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33066483 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16290 | |
dc.description.abstract | This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-gamma-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Risk | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Breast Neoplasms | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Phospholipids | * |
dc.subject.mesh | Case-Control Studies | * |
dc.subject.mesh | Fatty Acids | * |
dc.subject.mesh | Life Style | * |
dc.title | Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype | en |
dc.type | Journal Article | es |
dc.authorsophos | Lope, Virginia;Guerrero-Zotano, Ángel;Casas, Ana;Baena-Cañada, José Manuel;Bermejo, Begoña;Pérez-Gómez, Beatriz;Criado-Navarro, Inmaculada;Antolín, Silvia;Sánchez-Rovira, Pedro;Ramos-Vázquez, Manuel;Antón, Antonio;Castelló, Adela;García-Saénz, José Ángel;Muñoz, Montserrat;de Juan, Ana;Andrés, Raquel;Llombart-Cussac, Antonio;Hernando, Blanca;Franquesa, Rosa María;Caballero, Rosalia;Priego-Capote, Feliciano;Martín, Miguel;Pollán, Marina | |
dc.identifier.doi | 10.3390/nu12103132 | |
dc.identifier.pmid | 33066483 | |
dc.identifier.sophos | 36245 | |
dc.issue.number | 10 | es |
dc.journal.title | Nutrients | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de A Coruña - Complexo Hospitalario Universitario de A Coruña::Oncoloxía médica | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | estudios de casos y controles | * |
dc.subject.decs | estilo de vida | * |
dc.subject.decs | ácidos grasos | * |
dc.subject.decs | fosfolípidos | * |
dc.subject.decs | neoplasias de la mama | * |
dc.subject.decs | mediana edad | * |
dc.subject.decs | humanos | * |
dc.subject.decs | riesgo | * |
dc.subject.decs | adulto | * |
dc.subject.decs | conducta alimentaria | * |
dc.subject.keyword | CHUAC | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 12 | es |