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dc.contributor.authorGandoy Fieiras, Nerea
dc.contributor.authorGonzález Juanatey, José Ramón 
dc.contributor.authorEiras Penas, Sonia
dc.date.accessioned2022-04-26T07:42:12Z
dc.date.available2022-04-26T07:42:12Z
dc.date.issued2020
dc.identifier.issn1661-6596
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32290181es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16504
dc.description.abstractThe main energy substrate of adult cardiomyocytes for their contractility are the fatty acids. Its metabolism generates high ATP levels at the expense of high oxygen consumption in the mitochondria. Under low oxygen supply, they can get energy from other substrates, mainly glucose, lactate, ketone bodies, etc., but the mitochondrial dysfunction, in pathological conditions, reduces the oxidative metabolism. In consequence, fatty acids are stored into epicardial fat and its accumulation provokes inflammation, insulin resistance, and oxidative stress, which enhance the myocardium dysfunction. Some therapies focused on improvement the fatty acids entry into mitochondria have failed to demonstrate benefits on cardiovascular disorders. Oppositely, those therapies with effects on epicardial fat volume and inflammation might improve the oxidative metabolism of myocardium and might reduce the cardiovascular disease progression. This review aims at explain (a) the energy substrate adaptation of myocardium in physiological conditions, (b) the reduction of oxidative metabolism in pathological conditions and consequences on epicardial fat accumulation and insulin resistance, and (c) the reduction of cardiovascular outcomes after regulation by some therapies.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshPericardium*
dc.subject.meshAdipose Tissue*
dc.subject.meshMetabolic Networks and Pathways*
dc.subject.meshHeart Diseases*
dc.subject.meshHumans*
dc.subject.meshDisease Susceptibility*
dc.subject.meshHormones*
dc.subject.meshAnimals*
dc.subject.meshMyocardium*
dc.subject.meshHeart*
dc.subject.meshMolecular Targeted Therapy*
dc.subject.meshElectrophysiological Phenomena*
dc.titleMyocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targetsen
dc.typeJournal Articlees
dc.authorsophosGandoy-Fieiras, N.;Gonzalez-Juanatey, J. R.;Eiras, S.
dc.identifier.doi10.3390/ijms21072641
dc.identifier.pmid32290181
dc.identifier.sophos39056
dc.issue.number7es
dc.journal.titleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostela::Cardioloxíaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccess
dc.subject.decsanimales*
dc.subject.decsredes y vías metabólicas*
dc.subject.decshumanos*
dc.subject.decscorazón*
dc.subject.decstejido adiposo*
dc.subject.decsfenómenos electrofisiológicos*
dc.subject.decshormonas*
dc.subject.decsenfermedades cardíacas*
dc.subject.decspericardio*
dc.subject.decsterapia molecular selectiva*
dc.subject.decssusceptibilidad a enfermedades*
dc.subject.decsmiocardio*
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo de Revisiónes
dc.typesophosArtículo de Revisiónes
dc.volume.number21es


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Atribución 4.0 Internacional
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