Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
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Identificadores
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Fecha de publicación
2020Título de revista
Scientific Reports
Tipo de contenido
Journal Article
DeCS
prueba de tolerancia a la glucosa | insulina | resistencia a la insulina | adulto joven | obesidad | glucosa sanguínea | humanos | ayuno | diabetes mellitusMeSH
Humans | Insulin Resistance | Blood Glucose | Young Adult | Obesity | Diabetes Mellitus | Insulin | Fasting | Glucose Tolerance TestResumen
This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 +/- 3.84 years and BMI 37.92 +/- 4.85 kg/m(2)) and 28 age-matched healthy lean (24.56 +/- 3.50 years and BMI of 22.10 +/- 1.72 kg/m(2)) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
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