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Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
dc.contributor.author | Garcés, M. F. | |
dc.contributor.author | Buell-Acosta, J. D. | |
dc.contributor.author | Rodríguez-Navarro, H. A. | |
dc.contributor.author | Pulido-Sánchez, E. | |
dc.contributor.author | Rincon-Ramírez, J. J. | |
dc.contributor.author | Moreno-Ordóñez, D. C. | |
dc.contributor.author | Franco-Vega, R. | |
dc.contributor.author | Roncancio-Muñoz, J. S. | |
dc.contributor.author | Burgos-Cardenas, A. J. | |
dc.contributor.author | Lacunza, E. | |
dc.contributor.author | Castaño, J. P. | |
dc.contributor.author | Diéguez González, Carlos | |
dc.contributor.author | Nogueiras Pozo, Rubén | |
dc.contributor.author | Sanchez, E. | |
dc.contributor.author | Caminos, J. E. | |
dc.date.accessioned | 2022-04-26T07:42:16Z | |
dc.date.available | 2022-04-26T07:42:16Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | https://www.ncbi.nlm.nih.gov/pubmed/33273510 | es |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/16505 | |
dc.description.abstract | This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 +/- 3.84 years and BMI 37.92 +/- 4.85 kg/m(2)) and 28 age-matched healthy lean (24.56 +/- 3.50 years and BMI of 22.10 +/- 1.72 kg/m(2)) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues. | en |
dc.rights | Atribución 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Insulin Resistance | * |
dc.subject.mesh | Blood Glucose | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Obesity | * |
dc.subject.mesh | Diabetes Mellitus | * |
dc.subject.mesh | Insulin | * |
dc.subject.mesh | Fasting | * |
dc.subject.mesh | Glucose Tolerance Test | * |
dc.title | Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test | en |
dc.type | Journal Article | es |
dc.authorsophos | Garcés, M. F.;Buell-Acosta, J. D.;Rodríguez-Navarro, H. A.;Pulido-Sánchez, E.;Rincon-Ramírez, J. J.;Moreno-Ordóñez, D. C.;Franco-Vega, R.;Roncancio-Muñoz, J. S.;Burgos-Cardenas, A. J.;Lacunza, E.;Castaño, J. P.;Diéguez, C.;Nogueiras, R.;Sanchez, E.;Caminos, J. E. | |
dc.identifier.doi | 10.1038/s41598-020-77961-8 | |
dc.identifier.pmid | 33273510 | |
dc.identifier.sophos | 39058 | |
dc.issue.number | 1 | es |
dc.journal.title | Scientific Reports | es |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) | es |
dc.page.initial | 21118 | es |
dc.rights.accessRights | openAccess | |
dc.subject.decs | prueba de tolerancia a la glucosa | * |
dc.subject.decs | insulina | * |
dc.subject.decs | resistencia a la insulina | * |
dc.subject.decs | adulto joven | * |
dc.subject.decs | obesidad | * |
dc.subject.decs | glucosa sanguínea | * |
dc.subject.decs | humanos | * |
dc.subject.decs | ayuno | * |
dc.subject.decs | diabetes mellitus | * |
dc.subject.keyword | IDIS | es |
dc.typefides | Artículo Original | es |
dc.typesophos | Artículo Original | es |
dc.volume.number | 10 | es |