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dc.contributor.authorGarcés, M. F.
dc.contributor.authorBuell-Acosta, J. D.
dc.contributor.authorRodríguez-Navarro, H. A.
dc.contributor.authorPulido-Sánchez, E.
dc.contributor.authorRincon-Ramírez, J. J.
dc.contributor.authorMoreno-Ordóñez, D. C.
dc.contributor.authorFranco-Vega, R.
dc.contributor.authorRoncancio-Muñoz, J. S.
dc.contributor.authorBurgos-Cardenas, A. J.
dc.contributor.authorLacunza, E.
dc.contributor.authorCastaño, J. P.
dc.contributor.authorDiéguez González, Carlos
dc.contributor.authorNogueiras Pozo, Rubén
dc.contributor.authorSanchez, E.
dc.contributor.authorCaminos, J. E.
dc.date.accessioned2022-04-26T07:42:16Z
dc.date.available2022-04-26T07:42:16Z
dc.date.issued2020
dc.identifier.issn2045-2322
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/33273510es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16505
dc.description.abstractThis study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 +/- 3.84 years and BMI 37.92 +/- 4.85 kg/m(2)) and 28 age-matched healthy lean (24.56 +/- 3.50 years and BMI of 22.10 +/- 1.72 kg/m(2)) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshHumans*
dc.subject.meshInsulin Resistance*
dc.subject.meshBlood Glucose*
dc.subject.meshYoung Adult*
dc.subject.meshObesity*
dc.subject.meshDiabetes Mellitus*
dc.subject.meshInsulin*
dc.subject.meshFasting*
dc.subject.meshGlucose Tolerance Test*
dc.titleSerum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance testen
dc.typeJournal Articlees
dc.authorsophosGarcés, M. F.;Buell-Acosta, J. D.;Rodríguez-Navarro, H. A.;Pulido-Sánchez, E.;Rincon-Ramírez, J. J.;Moreno-Ordóñez, D. C.;Franco-Vega, R.;Roncancio-Muñoz, J. S.;Burgos-Cardenas, A. J.;Lacunza, E.;Castaño, J. P.;Diéguez, C.;Nogueiras, R.;Sanchez, E.;Caminos, J. E.
dc.identifier.doi10.1038/s41598-020-77961-8
dc.identifier.pmid33273510
dc.identifier.sophos39058
dc.issue.number1es
dc.journal.titleScientific Reportses
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.page.initial21118es
dc.rights.accessRightsopenAccess
dc.subject.decsprueba de tolerancia a la glucosa*
dc.subject.decsinsulina*
dc.subject.decsresistencia a la insulina*
dc.subject.decsadulto joven*
dc.subject.decsobesidad*
dc.subject.decsglucosa sanguínea*
dc.subject.decshumanos*
dc.subject.decsayuno*
dc.subject.decsdiabetes mellitus*
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number10es


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Atribución 4.0 Internacional
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