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An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk

dc.contributor.authorWu, L.
dc.contributor.authorYang, Y.
dc.contributor.authorGuo, X.
dc.contributor.authorShu, X. O.
dc.contributor.authorCai, Q.
dc.contributor.authorShu, X.
dc.contributor.authorLi, B.
dc.contributor.authorTao, R.
dc.contributor.authorWu, C.
dc.contributor.authorNikas, J. B.
dc.contributor.authorSun, Y.
dc.contributor.authorZhu, J.
dc.contributor.authorRoobol, M. J.
dc.contributor.authorGiles, G. G.
dc.contributor.authorBrenner, H.
dc.contributor.authorJohn, E. M.
dc.contributor.authorClements, J.
dc.contributor.authorGrindedal, E. M.
dc.contributor.authorPark, J. Y.
dc.contributor.authorStanford, J. L.
dc.contributor.authorKote-Jarai, Z.
dc.contributor.authorHaiman, C. A.
dc.contributor.authorEeles, R. A.
dc.contributor.authorZheng, W.
dc.contributor.authorLong, J.
dc.contributor.authorHenderson, B. E.
dc.contributor.authorSchumacher, F. R.
dc.contributor.authorEaston, D.
dc.contributor.authorBenlloch, S.
dc.contributor.authorOlama, A. A. A.
dc.contributor.authorMuir, K.
dc.contributor.authorBerndt, S. I.
dc.contributor.authorConti, D. V.
dc.contributor.authorWiklund, F.
dc.contributor.authorChanock, S.
dc.contributor.authorGapstur, S. M.
dc.contributor.authorStevens, V. L.
dc.contributor.authorTangen, C. M.
dc.contributor.authorBatra, J.
dc.contributor.authorGronberg, H.
dc.contributor.authorPashayan, N.
dc.contributor.authorSchleutker, J.
dc.contributor.authorAlbanes, D.
dc.contributor.authorWeinstein, S.
dc.contributor.authorWolk, A.
dc.contributor.authorWest, C.
dc.contributor.authorMucci, L.
dc.contributor.authorCancel-Tassin, G.
dc.contributor.authorKoutros, S.
dc.contributor.authorSorensen, K. D.
dc.contributor.authorNeal, D. E.
dc.contributor.authorHamdy, F. C.
dc.contributor.authorDonovan, J. L.
dc.contributor.authorTravis, R. C.
dc.contributor.authorHamilton, R. J.
dc.contributor.authorIngles, S. A.
dc.contributor.authorRosenstein, B. S.
dc.contributor.authorLu, Y. J.
dc.contributor.authorKibel, A. S.
dc.contributor.authorVega Gliemmo, Ana
dc.contributor.authorKogevinas, M.
dc.contributor.authorPenney, K. L.
dc.contributor.authorCybulski, C.
dc.contributor.authorNordestgaard, B. G.
dc.contributor.authorMaier, C.
dc.contributor.authorKim, J.
dc.contributor.authorTeixeira, M. R.
dc.contributor.authorNeuhausen, S. L.
dc.contributor.authorDe Ruyck, K.
dc.contributor.authorRazack, A.
dc.contributor.authorNewcomb, L. F.
dc.contributor.authorGamulin, M.
dc.contributor.authorKaneva, R.
dc.contributor.authorUsmani, N.
dc.contributor.authorClaessens, F.
dc.contributor.authorTownsend, P. A.
dc.contributor.authorGago Dominguez, Manuela
dc.contributor.authorMenegaux, F.
dc.contributor.authorKhaw, K. T.
dc.contributor.authorCannon-Albright, L.
dc.contributor.authorPandha, H.
dc.contributor.authorThibodeau, S. N.
dc.contributor.authorHunter, D. J.
dc.contributor.authorBlot, W. J.
dc.contributor.authorRiboli, E.
dc.date.accessioned2022-05-19T08:32:28Z
dc.date.available2022-05-19T08:32:28Z
dc.date.issued2020
dc.identifier.issn2041-1723
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pubmed/32764609es
dc.identifier.urihttp://hdl.handle.net/20.500.11940/16726
dc.description.abstractIt remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls). We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes.en
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshRisk Factors*
dc.subject.meshHumans*
dc.subject.meshGenetic Association Studies*
dc.subject.meshProstatic Neoplasms*
dc.subject.meshDNA Methylation*
dc.subject.meshCase-Control Studies*
dc.subject.meshGenetic Predisposition to Disease*
dc.subject.meshCpG Islands*
dc.titleAn integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risken
dc.typeJournal Articlees
dc.contributor.authorcorpPRACTICAL consortium
dc.contributor.authorcorpCRUK Consortium
dc.contributor.authorcorpBPC3 Consortium
dc.contributor.authorcorpCAPS Consortium
dc.contributor.authorcorpPEGASUS Consortium
dc.authorsophosWu, L.;Yang, Y.;Guo, X.;Shu, X. O.;Cai, Q.;Shu, X.;Li, B.;Tao, R.;Wu, C.;Nikas, J. B.;Sun, Y.;Zhu, J.;Roobol, M. J.;Giles, G. G.;Brenner, H.;John, E. M.;Clements, J.;Grindedal, E. M.;Park, J. Y.;Stanford, J. L.;Kote-Jarai, Z.;Haiman, C. A.;Eeles, R. A.;Zheng, W.;Long, J.;Henderson, B. E.;Schumacher, F. R.;Easton, D.;Benlloch, S.;Olama, A. A. A.;Muir, K.;Berndt, S. I.;Conti, D. V.;Wiklund, F.;Chanock, S.;Gapstur, S. M.;Stevens, V. L.;Tangen, C. M.;Batra, J.;Gronberg, H.;Pashayan, N.;Schleutker, J.;Albanes, D.;Weinstein, S.;Wolk, A.;West, C.;Mucci, L.;Cancel-Tassin, G.;Koutros, S.;Sorensen, K. D.;Neal, D. E.;Hamdy, F. C.;Donovan, J. L.;Travis, R. C.;Hamilton, R. J.;Ingles, S. A.;Rosenstein, B. S.;Lu, Y. J.;Kibel, A. S.;Vega, A.;Kogevinas, M.;Penney, K. L.;Cybulski, C.;Nordestgaard, B. G.;Maier, C.;Kim, J.;Teixeira, M. R.;Neuhausen, S. L.;De Ruyck, K.;Razack, A.;Newcomb, L. F.;Gamulin, M.;Kaneva, R.;Usmani, N.;Claessens, F.;Townsend, P. A.;Dominguez, M. G.;Menegaux, F.;Khaw, K. T.;Cannon-Albright, L.;Pandha, H.;Thibodeau, S. N.;Hunter, D. J.;Blot, W. J.;Riboli, E.;The, Practical consortium;Consortium, Cruk;Consortium, B. P. C.;Consortium, Caps;Consortium, Pegasus
dc.identifier.doi10.1038/s41467-020-17673-9
dc.identifier.pmid32764609
dc.identifier.sophos40229
dc.issue.number1es
dc.journal.titleNature Communicationses
dc.organizationServizo Galego de Saúde::Dirección Xeral de Asistencia Sanitaria::Fundación Pública Galega de Medicina Xenómicaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago de Compostela - Complexo Hospitalario Universitario de Santiago de Compostelaes
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)es
dc.rights.accessRightsopenAccess
dc.subject.decsestudios de asociación genética*
dc.subject.decsestudios de casos y controles*
dc.subject.decsneoplasias de la próstata*
dc.subject.decsfactores de riesgo*
dc.subject.decshumanos*
dc.subject.decsislas CpG*
dc.subject.decsmetilación del ADN*
dc.subject.decspredisposición genética a la enfermedad*
dc.subject.keywordFGMXes
dc.subject.keywordCHUSes
dc.subject.keywordIDISes
dc.typefidesArtículo Originales
dc.typesophosArtículo Originales
dc.volume.number11es


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Nat Commun. 2020 Aug 6;11(1):3905

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