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Interleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1

dc.contributor.authorPoveda López, Eva 
dc.contributor.authorFitzgerald, Wendy
dc.contributor.authorMartínez Reglero, Cristina
dc.contributor.authorPerez Gonzalez, Alexandre
dc.contributor.authorMariño Callejo, Ana Isabel 
dc.contributor.authorÁlvarez Díaz, Hortensia 
dc.contributor.authorValcarce Pardeiro, Nieves 
dc.contributor.authorLlibre, Josep Maria
dc.contributor.authorMoreno Guillén, Santiago
dc.contributor.authorMuñoz Fernández, Maria Angeles
dc.contributor.authorRuiz-Mateos, Ezequiel
dc.contributor.authorMargolis, Leonid
dc.contributor.authorLederman, Michael M
dc.contributor.authorFreeman, Michael L
dc.date.accessioned2025-03-25T08:56:34Z
dc.date.available2025-03-25T08:56:34Z
dc.date.issued2023-06-15
dc.identifier.otherhttps://academic.oup.com/jid/article/227/12/1381/7040365?login=truees
dc.identifier.urihttp://hdl.handle.net/20.500.11940/19782
dc.description.abstractPlasma extracellular vesicle (EV)-associated cytokines were quantified in people with HIV (PWH) with different virological control status, including elite controllers (EC) who maintain persistent control (PC) or not (TC). Cytokine signatures and pathways were determined for each group. Median EV-associated cytokine levels were higher among PWH than HIV-uninfected. EC showed the highest levels of EV-associated cytokines among PWH with PC levels higher than TC levels. IL-18 levels best distinguished PWH from uninfected controls, and EC from ART-treated, and IL-3 distinguished PC from TC. The role of EV-cytokines in intercellular communication and endogenous control of HIV expression should be investigated further.es
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)es
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.meshInterleukin-18 *
dc.subject.meshSpain *
dc.subject.meshExtracellular Vesicles *
dc.subject.meshHIV Seropositivity *
dc.subject.meshHumans *
dc.subject.meshHIV *
dc.subject.meshInterleukin-3 *
dc.subject.meshHIV Infections *
dc.subject.meshCommunicable Diseases *
dc.subject.meshCytokines *
dc.subject.meshElite Controllers *
dc.subject.meshHIV-1 *
dc.subject.meshCD4-Positive T-Lymphocytes *
dc.titleInterleukin 18 (IL-18) and IL-3 in Extracellular Vesicles: Biomarkers for Durable Elite Control of HIV-1es
dc.typeArtigoes
dc.identifier.doi10.1093/infdis/jiad042
dc.identifier.essn1537-6613
dc.identifier.pmid36790818
dc.issue.number12es
dc.journal.titleThe Journal of infectious diseaseses
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Instituto de Investigación Sanitaria Galicia Sur ((IISGS)es
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Ferrol – Complexo Hospitalario Universitario de Ferrol::Medicina Internaes
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.)::Área Sanitaria de Vigo - Complexo Hospitalario Universitario de Vigo::Medicina Internaes
dc.page.initial1381es
dc.page.final1385es
dc.relation.projectIDIISCIII/AES2016/02159es
dc.relation.projectIDIISCIII/AES2018/00034es
dc.relation.projectIDIISCIII/AES2019/00747es
dc.relation.projectIDIISCIII/AES2022/01341es
dc.relation.projectIDIISCIII/AES2022/01796es
dc.relation.projectIDIISCIII/AES2020/00243es
dc.relation.projectIDIISCIII/RD16/0025/0026es
dc.relation.projectIDIISCIII/RD16/0025/0020es
dc.rights.accessRightsopenAccesses
dc.subject.decsinterleucina-18 *
dc.subject.decslinfocitos T CD4-positivos *
dc.subject.decsenfermedades transmisibles *
dc.subject.decsinfecciones por VIH *
dc.subject.decshumanos *
dc.subject.decsseropositividad al VIH *
dc.subject.decsVIH *
dc.subject.decsVIH-1 *
dc.subject.decsinterleucina 3 *
dc.subject.decscitocinas *
dc.subject.keywordCHUVIes
dc.subject.keywordIISGSes
dc.subject.keywordCHUFes
dc.typefidesArtigo Científico (inclue Orixinal, Orixinal breve, Revisión Sistemática e Meta-análisis)es
dc.typesophosArtículo Originales
dc.volume.number227es


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J Infect Dis . 2023 Jun 15;227(12):1381-1385. doi: 10.1093/infdis/jiad042.

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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