Mostrar o rexistro simple do ítem

dc.contributor.authorHo, A.*
dc.contributor.authorOrton, R.*
dc.contributor.authorTayler, R.*
dc.contributor.authorAsamaphan, P.*
dc.contributor.authorHerder, V.*
dc.contributor.authorDavis, C.*
dc.contributor.authorTong, L.*
dc.contributor.authorSmollett, K.*
dc.contributor.authorManali, M.*
dc.contributor.authorAllan, J.*
dc.contributor.authorRawlik, K.*
dc.contributor.authorMcDonald, S.E.*
dc.contributor.authorVink, E.*
dc.contributor.authorPollock, L.*
dc.contributor.authorGannon, L.*
dc.contributor.authorEvans, C.*
dc.contributor.authorMcMenamin, J.*
dc.contributor.authorRoy, K.*
dc.contributor.authorMarsh, K.*
dc.contributor.authorDivala, T.*
dc.contributor.authorHolden, M.T.G.*
dc.contributor.authorLockhart, M.*
dc.contributor.authorYirrell, D.*
dc.contributor.authorCurrie, S.*
dc.contributor.authorO'Leary, M.*
dc.contributor.authorHenderson, D.*
dc.contributor.authorShepherd, S.J.*
dc.contributor.authorJackson, C.*
dc.contributor.authorGunson, R.*
dc.contributor.authorMacLean, A.*
dc.contributor.authorMcInnes, N.*
dc.contributor.authorBradley-Stewart, A.*
dc.contributor.authorBattle, R.*
dc.contributor.authorHollenbach, J.A.*
dc.contributor.authorHenderson, P.*
dc.contributor.authorOdam, M.*
dc.contributor.authorChikowore, P.*
dc.contributor.authorOosthuyzen, W.*
dc.contributor.authorChand, M.*
dc.contributor.authorHamilton, M.S.*
dc.contributor.authorEstrada-Rivadeneyra, D.*
dc.contributor.authorLevin, M.*
dc.contributor.authorAvramidis, N.*
dc.contributor.authorPairo-Castineira, E.*
dc.contributor.authorVitart, V.*
dc.contributor.authorWilkie, C.*
dc.contributor.authorCunnington, A.*
dc.contributor.authorHerberg, J.*
dc.contributor.authorKaforou, M.*
dc.contributor.authorWright, V.*
dc.contributor.authorBellos, E.*
dc.contributor.authorBroderick, C.*
dc.contributor.authorChannon-Wells, S.*
dc.contributor.authorCooray, S.*
dc.contributor.authorDe, T.*
dc.contributor.authorD'Souza, G.*
dc.contributor.authorElorrieta, L.E.*
dc.contributor.authorGalassini, R.*
dc.contributor.authorHabgood-Coote, D.*
dc.contributor.authorJackson, H.*
dc.contributor.authorKavanagh, J.*
dc.contributor.authorMarjaneh, M.M.*
dc.contributor.authorMenikou, S.*
dc.contributor.authorNichols, S.*
dc.contributor.authorNijman, R.*
dc.contributor.authorPatel, H.*
dc.contributor.authorPennisi, I.*
dc.contributor.authorPowell, O.*
dc.contributor.authorReid, R.*
dc.contributor.authorShah, P.*
dc.contributor.authorVito, O.*
dc.contributor.authorWhittaker, E.*
dc.contributor.authorWilson, C.*
dc.contributor.authorWomersley, R.*
dc.contributor.authorAbdulla, A.*
dc.contributor.authorDarnell, S.*
dc.contributor.authorMustafa, S.*
dc.contributor.authorGeorgiou, P.*
dc.contributor.authorManzano, J.-R.*
dc.contributor.authorMoser, N.*
dc.contributor.authorCarter, M.*
dc.contributor.authorTibby, S.*
dc.contributor.authorCohen, J.*
dc.contributor.authorDavis, F.*
dc.contributor.authorKenny, J.*
dc.contributor.authorWellman, P.*
dc.contributor.authorWhite, M.*
dc.contributor.authorFish, M.*
dc.contributor.authorJennings, A.*
dc.contributor.authorShankar-Hari, M.*
dc.contributor.authorFidler, K.*
dc.contributor.authorAgranoff, D.*
dc.contributor.authorRichmond, V.*
dc.contributor.authorSeal, M.*
dc.contributor.authorFaust, S.*
dc.contributor.authorOwen, D.*
dc.contributor.authorEnsom, R.*
dc.contributor.authorMcKay, S.*
dc.contributor.authorMondo, D.*
dc.contributor.authorShaji, M.*
dc.contributor.authorSchranz, R.*
dc.contributor.authorRughnani, P.*
dc.contributor.authorAnpananthar, A.*
dc.contributor.authorLiebeschuetz, S.*
dc.contributor.authorRiddell, A.*
dc.contributor.authorKhalid, N.*
dc.contributor.authorMalcolm, I.L.*
dc.contributor.authorSimagan, T.*
dc.contributor.authorPeters, M.*
dc.contributor.authorBamford, A.*
dc.contributor.authorO'Neill, L.*
dc.contributor.authorPathan, N.*
dc.contributor.authorDaubney, E.*
dc.contributor.authorWhite, D.*
dc.contributor.authorHeightman, M.*
dc.contributor.authorEisen, S.*
dc.contributor.authorSegal, T.*
dc.contributor.authorWellings, L.*
dc.contributor.authorDrysdale, S.B.*
dc.contributor.authorBranch, N.*
dc.contributor.authorHamzah, L.*
dc.contributor.authorJarman, H.*
dc.contributor.authorNyirenda, M.*
dc.contributor.authorCapozzi, L.*
dc.contributor.authorGardiner, E.*
dc.contributor.authorMoots, R.*
dc.contributor.authorNasher, M.*
dc.contributor.authorHanson, A.*
dc.contributor.authorLinforth, M.*
dc.contributor.authorO'Riordan, S.*
dc.contributor.authorEllis, D.*
dc.contributor.authorDeep, A.*
dc.contributor.authorCaro, I.*
dc.contributor.authorShackley, F.*
dc.contributor.authorBellini, A.*
dc.contributor.authorGormley, S.*
dc.contributor.authorNeshat, S.*
dc.contributor.authorScholefield, B.J.*
dc.contributor.authorRobbins, C.*
dc.contributor.authorWinmill, H.*
dc.contributor.authorPaulus, S.C.*
dc.contributor.authorPollard, A.J.*
dc.contributor.authorAnthony, M.*
dc.contributor.authorHopton, S.*
dc.contributor.authorMiller, D.*
dc.contributor.authorOliver, Z.*
dc.contributor.authorBeer, S.*
dc.contributor.authorWard, B.*
dc.contributor.authorShrestha, S.*
dc.contributor.authorPollard, A.J.*
dc.contributor.authorGurung, M.*
dc.contributor.authorAmatya, P.*
dc.contributor.authorPokhrel, B.*
dc.contributor.authorBijukchhe, S.M.*
dc.contributor.authorLubinda, T.*
dc.contributor.authorKelly, S.*
dc.contributor.authorO'Reilly, P.*
dc.contributor.authorMartinón Torres, Federico *
dc.contributor.authorSalas, A.*
dc.contributor.authorGonzález, F.Á.*
dc.contributor.authorBello, X.*
dc.contributor.authorBen García, M.*
dc.contributor.authorCarnota, S.*
dc.contributor.authorCebey-López, M.*
dc.contributor.authorCurrás Tuala, María José*
dc.contributor.authorSuárez, C.D.*
dc.contributor.authorVicente, L.G.*
dc.contributor.authorGómez Carballa, Alberto*
dc.contributor.authorRial, J.G.*
dc.contributor.authorIglesias, P.L.*
dc.contributor.authorMartinón-Torres, N.*
dc.contributor.authorSánchez, J.M.M.*
dc.contributor.authorPérez, B.M.*
dc.contributor.authorPardo Seco, Jacobo José*
dc.contributor.authorRodríguez, L.P.*
dc.contributor.authorPischedda, Sara*
dc.contributor.authorVázquez, S.R.*
dc.contributor.authorCalle, I.R.*
dc.contributor.authorRodríguez-Tenreiro, C.*
dc.contributor.authorRedondo Collazo, Lorenzo *
dc.contributor.authorOra, M.S.*
dc.contributor.authorFernández, S.S.*
dc.contributor.authorTrasorras, C.S.*
dc.contributor.authorIglesias, M.V.*
dc.contributor.authorCarrol, E.D.*
dc.contributor.authorCocklin, E.*
dc.contributor.authorKhanijau, A.*
dc.contributor.authorLenihan, R.*
dc.contributor.authorLewis-Burke, N.*
dc.contributor.authorNewall, K.*
dc.contributor.authorRomaine, S.*
dc.contributor.authorTsolia, M.*
dc.contributor.authorEleftheriou, I.*
dc.contributor.authorSpyridis, N.*
dc.contributor.authorTambouratzi, M.*
dc.contributor.authorMaritsi, D.*
dc.contributor.authorMarmarinos, A.*
dc.contributor.authorXagorari, M.*
dc.contributor.authorPanagiota, L.*
dc.contributor.authorAggelos, P.*
dc.contributor.authorKarolina, A.*
dc.contributor.authorCharalambos, G.*
dc.contributor.authorMarkos, M.*
dc.contributor.authorMichalis, V.*
dc.contributor.authorIoanna, S.*
dc.contributor.authorEmonts, M.*
dc.contributor.authorLim, E.*
dc.contributor.authorIsaacs, J.*
dc.contributor.authorBell, K.*
dc.contributor.authorCrulley, S.*
dc.contributor.authorFabian, D.*
dc.contributor.authorThomson, E.*
dc.contributor.authorWallia, D.*
dc.contributor.authorMiller, C.*
dc.contributor.authorBell, A.*
dc.contributor.authorvan der Velden, F.J.S.*
dc.contributor.authorShenton, G.*
dc.contributor.authorPrice, A.*
dc.contributor.authorTreloar, O.*
dc.contributor.authorThomas, D.*
dc.contributor.authorRojo, P.*
dc.contributor.authorEpalza, C.*
dc.contributor.authorVillaverde, S.*
dc.contributor.authorMárquez, S.*
dc.contributor.authorGijón, M.*
dc.contributor.authorMachín, F.*
dc.contributor.authorCabello, L.*
dc.contributor.authorHernández, I.*
dc.contributor.authorGutiérrez, L.*
dc.contributor.authorManzanares, Á.*
dc.contributor.authorKuijpers, T.W.T.*
dc.contributor.authorvan de Kuip, M.M.*
dc.contributor.authorvan Furth, A.M.M.*
dc.contributor.authorvan den Berg, J.M.M.*
dc.contributor.authorBiesbroek, G.*
dc.contributor.authorVerkuil, F.*
dc.contributor.authorvan der Zee, C.C.W.*
dc.contributor.authorPajkrt, D.*
dc.contributor.authorvan Hensbroek, M.B.*
dc.contributor.authorSchonenberg, D.*
dc.contributor.authorGruppen, M.*
dc.contributor.authorNagelkerke, S.*
dc.contributor.authorJansen, M.H.*
dc.contributor.authorGoetschalckx, I.*
dc.contributor.authorRomani, L.*
dc.contributor.authorDe Luca, M.*
dc.contributor.authorChiurchiù, S.*
dc.contributor.authorDi Giuseppe, M.*
dc.contributor.authorVermont, C.L.*
dc.contributor.authorMoll, H.A.*
dc.contributor.authorBorensztajn, D.M.*
dc.contributor.authorHagedoorn, N.N.*
dc.contributor.authorTan, C.*
dc.contributor.authorZachariasse, J.*
dc.contributor.authorstudents, M.*
dc.contributor.authorDik, W.*
dc.contributor.authorShen, C.-F.K.*
dc.contributor.authorZavadska, D.*
dc.contributor.authorLaivacuma, S.*
dc.contributor.authorRudzate, A.*
dc.contributor.authorStoldere, D.*
dc.contributor.authorBarzdina, A.*
dc.contributor.authorBarzdina, E.*
dc.contributor.authorMadelane, M.*
dc.contributor.authorGravele, D.*
dc.contributor.authorSvile, D.*
dc.contributor.authorBasmaci, R.*
dc.contributor.authorLachaume, N.*
dc.contributor.authorBories, P.*
dc.contributor.authorTkhayat, R.B.*
dc.contributor.authorChériaux, L.*
dc.contributor.authorDavoust, J.*
dc.contributor.authorOng, K.-T.*
dc.contributor.authorCotillon, M.*
dc.contributor.authorde Groc, T.*
dc.contributor.authorLe, S.*
dc.contributor.authorVergnault, N.*
dc.contributor.authorSée, H.*
dc.contributor.authorCohen, L.*
dc.contributor.authorde Tugny, A.*
dc.contributor.authorDanekova, N.*
dc.contributor.authorMommert-Tripon, M.*
dc.contributor.authorBrengel-Pesce, K.*
dc.contributor.authorPokorn, M.*
dc.contributor.authorKolnik, M.*
dc.contributor.authorAv?in, T.*
dc.contributor.authorAvramoska, T.*
dc.contributor.authorBahovec, N.*
dc.contributor.authorBogovi?, P.*
dc.contributor.authorKitanovski, L.*
dc.contributor.authorNahtigal, M.*
dc.contributor.authorPapst, L.*
dc.contributor.authorSrovin, T.P.*
dc.contributor.authorStrle, F.*
dc.contributor.authorSrp?i?, A.*
dc.contributor.authorVincek, K.*
dc.contributor.authorvan der Flier, M.*
dc.contributor.authorTissing, W.J.E.*
dc.contributor.authorWösten-van Asperen, R.M.*
dc.contributor.authorVastert, S.J.*
dc.contributor.authorVijlbrief, D.C.*
dc.contributor.authorBont, L.J.*
dc.contributor.authorWolfs, T.F.W.*
dc.contributor.authorBeudeker, C.R.*
dc.contributor.authorAgyeman, P.*
dc.contributor.authorSchlapbach, L.*
dc.contributor.authorAebi, C.*
dc.contributor.authorUsman, M.*
dc.contributor.authorSchlüchter, S.*
dc.contributor.authorWyss, V.*
dc.contributor.authorSchöbi, N.*
dc.contributor.authorZimmermann, E.*
dc.contributor.authorMeier, M.*
dc.contributor.authorWeber, K.*
dc.contributor.authorAgyeman, P.*
dc.contributor.authorSchlapbach, L.J.*
dc.contributor.authorGiannoni, E.*
dc.contributor.authorStocker, M.*
dc.contributor.authorPosfay-Barbe, K.M.*
dc.contributor.authorHeininger, U.*
dc.contributor.authorBernhard-Stirnemann, S.*
dc.contributor.authorNiederer-Loher, A.*
dc.contributor.authorKahlert, C.*
dc.contributor.authorNatalucci, G.*
dc.contributor.authorRelly, C.*
dc.contributor.authorRiedel, T.*
dc.contributor.authorAebi, C.*
dc.contributor.authorBerger, C.*
dc.contributor.authorFink, C.*
dc.contributor.authorVoice, M.*
dc.contributor.authorCalvo-Bado, L.*
dc.contributor.authorSteele, M.*
dc.contributor.authorHolden, J.*
dc.contributor.authorEvans, B.*
dc.contributor.authorStevens, J.*
dc.contributor.authorMatthews, P.*
dc.contributor.authorBilling, K.*
dc.contributor.authorZenz, W.*
dc.contributor.authorBinder, A.*
dc.contributor.authorKohlmaier, B.*
dc.contributor.authorKohlfürst, D.S.*
dc.contributor.authorSchweintzger, N.A.*
dc.contributor.authorZurl, C.*
dc.contributor.authorHösele, S.*
dc.contributor.authorLeitner, M.*
dc.contributor.authorPölz, L.*
dc.contributor.authorRusu, A.*
dc.contributor.authorRajic, G.*
dc.contributor.authorStoiser, B.*
dc.contributor.authorStrempfl, M.*
dc.contributor.authorSagmeister, M.G.*
dc.contributor.authorBauchinger, S.*
dc.contributor.authorBenesch, M.*
dc.contributor.authorCeolotto, A.*
dc.contributor.authorEber, E.*
dc.contributor.authorGallistl, S.*
dc.contributor.authorHaidl, H.*
dc.contributor.authorHauer, A.*
dc.contributor.authorHude, C.*
dc.contributor.authorKapper, A.*
dc.contributor.authorKeldorfer, M.*
dc.contributor.authorLöffler, S.*
dc.contributor.authorNiedrist, T.*
dc.contributor.authorPilch, H.*
dc.contributor.authorPfleger, A.*
dc.contributor.authorPfurtscheller, K.*
dc.contributor.authorRödl, S.*
dc.contributor.authorSkrabl-Baumgartner, A.*
dc.contributor.authorStrenger, V.*
dc.contributor.authorWallner, E.*
dc.contributor.authorTempel, D.*
dc.contributor.authorvan Keulen, D.*
dc.contributor.authorStrijbosch, A.M.*
dc.contributor.authorTauchert, M.K.*
dc.contributor.authorvon Both, U.*
dc.contributor.authorKolberg, L.*
dc.contributor.authorSchmied, P.*
dc.contributor.authorAlba-Alejandre, I.*
dc.contributor.authorDanhauser, K.*
dc.contributor.authorHaas, N.*
dc.contributor.authorHoffmann, F.*
dc.contributor.authorGriese, M.*
dc.contributor.authorFeuchtinger, T.*
dc.contributor.authorJuranek, S.*
dc.contributor.authorKappler, M.*
dc.contributor.authorLurz, E.*
dc.contributor.authorMaier, E.*
dc.contributor.authorReiter, K.*
dc.contributor.authorSchoen, C.*
dc.contributor.authorSchroepf, S.*
dc.contributor.authorYeung, S.*
dc.contributor.authorDewez, M.*
dc.contributor.authorBath, D.*
dc.contributor.authorFitchett, E.*
dc.contributor.authorCresswell, F.*
dc.contributor.authorMomodou, S.*
dc.contributor.authorUsuf, E.*
dc.contributor.authorNdure, E.*
dc.contributor.authorBojang, K.*
dc.contributor.authorRoca, A.*
dc.contributor.authorSarr, I.*
dc.contributor.authorSemple, M.G.*
dc.contributor.authorCarson, G.*
dc.contributor.authorOpenshaw, P.J.M.*
dc.contributor.authorDunning, J.*
dc.contributor.authorMerson, L.*
dc.contributor.authorRussell, C.D.*
dc.contributor.authorDorward, D.*
dc.contributor.authorZambon, M.*
dc.contributor.authorChand, M.*
dc.contributor.authorTedder, R.S.*
dc.contributor.authorKhoo, S.*
dc.contributor.authorTurtle, L.C.W.*
dc.contributor.authorSolomon, T.*
dc.contributor.authorIjaz, S.*
dc.contributor.authorFletcher, T.*
dc.contributor.authorThomson, E.C.*
dc.contributor.authorPrice, N.*
dc.contributor.authorBreuer, J.*
dc.contributor.authorde Silva, T.*
dc.contributor.authorDonohue, C.*
dc.contributor.authorHardwick, H.*
dc.contributor.authorObosi, L.*
dc.contributor.authorClohisey, S.*
dc.contributor.authorLaw, A.*
dc.contributor.authorNorris, L.*
dc.contributor.authorTait, S.*
dc.contributor.authorWham, M.*
dc.contributor.authorClark, R.*
dc.contributor.authorCoutts, A.*
dc.contributor.authorDonnelly, L.*
dc.contributor.authorFawkes, A.*
dc.contributor.authorGilchrist, T.*
dc.contributor.authorHafezi, K.*
dc.contributor.authorMacGillivray, L.*
dc.contributor.authorMaclean, A.*
dc.contributor.authorMcCafferty, S.*
dc.contributor.authorMorrice, K.*
dc.contributor.authorMurphy, L.*
dc.contributor.authorWrobel, N.*
dc.contributor.authorShaw, V.*
dc.contributor.authorAhmed, K.A.*
dc.contributor.authorArmstrong, J.A.*
dc.contributor.authorLett, L.*
dc.contributor.authorHenderson, P.*
dc.contributor.authorPollock, L.*
dc.contributor.authorKishore, S.*
dc.contributor.authorBrotherton, H.*
dc.contributor.authorArmstrong, L.*
dc.contributor.authorMitra, A.*
dc.contributor.authorDall, A.*
dc.contributor.authorBohmova, K.*
dc.contributor.authorLogan, S.*
dc.contributor.authorGannon, L.*
dc.contributor.authorAgwuh, K.*
dc.contributor.authorChukkambotla, S.*
dc.contributor.authorDuRand, I.*
dc.contributor.authorFullerton, D.*
dc.contributor.authorGar, S.*
dc.contributor.authorGraham, C.*
dc.contributor.authorGrammatikopoulos, T.*
dc.contributor.authorHartshorn, S.*
dc.contributor.authorHodgson, L.*
dc.contributor.authorJennings, P.*
dc.contributor.authorKoshy, G.*
dc.contributor.authorLeiner, T.*
dc.contributor.authorLimb, J.*
dc.contributor.authorLittle, J.*
dc.contributor.authorLogan, S.*
dc.contributor.authorMatovu, E.*
dc.contributor.authorMcGill, F.*
dc.contributor.authorMorris, C.*
dc.contributor.authorMorrice, J.*
dc.contributor.authorPrice, D.*
dc.contributor.authorReschreiter, H.*
dc.contributor.authorReynolds, T.*
dc.contributor.authorWhittaker, P.*
dc.contributor.authorJordan, T.*
dc.contributor.authorTayler, R.*
dc.contributor.authorIrving, C.*
dc.contributor.authorJack, K.*
dc.contributor.authorRamsay, M.*
dc.contributor.authorMillar, M.*
dc.contributor.authorMilligan, B.*
dc.contributor.authorHickey, N.*
dc.contributor.authorConnon, M.*
dc.contributor.authorWard, C.*
dc.contributor.authorBeveridge, L.*
dc.contributor.authorMacFarlane, S.*
dc.contributor.authorLeitch, K.*
dc.contributor.authorBell, C.*
dc.contributor.authorFinlayson, L.*
dc.contributor.authorDawson, J.*
dc.contributor.authorCandlish, J.*
dc.contributor.authorMcGenily, L.*
dc.contributor.authorRoome, T.*
dc.contributor.authorDiaba, C.*
dc.contributor.authorPlayer, J.*
dc.contributor.authorPowell, N.*
dc.contributor.authorHowman, R.*
dc.contributor.authorBurling, S.*
dc.contributor.authorFloyd, S.*
dc.contributor.authorFarmer, S.*
dc.contributor.authorFerguson, S.*
dc.contributor.authorHope, S.*
dc.contributor.authorRubick, L.*
dc.contributor.authorSwingler, R.*
dc.contributor.authorCollins, E.*
dc.contributor.authorSpencer, C.*
dc.contributor.authorJones, A.*
dc.contributor.authorWilson, B.*
dc.contributor.authorArmstrong, D.*
dc.contributor.authorBirt, M.*
dc.contributor.authorDickinson, H.*
dc.contributor.authorHarper, R.*
dc.contributor.authorMartin, D.*
dc.contributor.authorRoff, A.*
dc.contributor.authorMills, S.*
dc.contributor.authorPalmarini, M.*
dc.contributor.authorRay, S.*
dc.contributor.authorRobertson, D.L.*
dc.contributor.authorda Silva Filipe, A.*
dc.contributor.authorWillett, B.J.*
dc.contributor.authorBreuer, J.*
dc.contributor.authorSemple, M.G.*
dc.contributor.authorTurner, D.*
dc.contributor.authorBaillie, J.K.*
dc.contributor.authorThomson, E.C.*
dc.date.accessioned2025-09-05T09:21:40Z
dc.date.available2025-09-05T09:21:40Z
dc.date.issued2023
dc.identifier.citationHo A, Orton R, Tayler R, Asamaphan P, Herder V, Davis C, et al. Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature. 2023;617(7961):555-63.
dc.identifier.issn1476-4687
dc.identifier.otherhttps://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6f5
dc.identifier.urihttp://hdl.handle.net/20.500.11940/21025
dc.description.abstractAn outbreak of acute hepatitis of unknown aetiology in children was reported in Scotland 1 in April 2022 and has now been identified in 35 countries 2. Several recent studies have suggested an association with human adenovirus with this outbreak, a virus not commonly associated with hepatitis. Here we report a detailed case-control investigation and find an association between adeno-associated virus 2 (AAV2) infection and host genetics in disease susceptibility. Using next-generation sequencing, PCR with reverse transcription, serology and in situ hybridization, we detected recent infection with AAV2 in plasma and liver samples in 26 out of 32 (81%) cases of hepatitis compared with 5 out of 74 (7%) of samples from unaffected individuals. Furthermore, AAV2 was detected within ballooned hepatocytes alongside a prominent T cell infiltrate in liver biopsy samples. In keeping with a CD4+ T-cell-mediated immune pathology, the human leukocyte antigen (HLA) class II HLA-DRB1*04:01 allele was identified in 25 out of 27 cases (93%) compared with a background frequency of 10 out of 64 (16%; P = 5.49 × 10?12). In summary, we report an outbreak of acute paediatric hepatitis associated with AAV2 infection (most likely acquired as a co-infection with human adenovirus that is usually required as a 'helper virus' to support AAV2 replication) and disease susceptibility related to HLA class II status.
dc.description.sponsorshipWe wish to acknowledge the contribution of the participating children and their parents who agreed to participate in the ISARIC CCP-UK and DIAMONDS studies, and the research teams who recruited the patients; S.Bennett-Slater from NHS Greater Glasgow and Clyde for assisting with sample location and testing; the histopathology team, Veterinary Diagnostic, University of Glasgow, for excellent technical assistance; P.Murcia for providing resources and advice; P.Olmo for administrative assistance; and E.J.Kremer from the Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier and A.Baker, University of Edinburgh, for advice. The work was funded by Public Health Scotland, the National Institute for Health Research (NIHR; award CO-CIN-01) and the Medical Research Council (MRC; grants MR/X010252/1, MC_UU_1201412, MC_UU_12018/12, MC_PC_19059, MC_PC_19025 and MC_PC_22004). DIAMONDS is funded by the European Union Horizon 2020 programme; grant 848196). M.P. acknowledges funding support from the Wellcome Trust (206369/Z/17/Z). M.G.S. acknowledges funding support from The Pandemic Institute, Liverpool and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool, and UK Health Security Agency. J.K.B. acknowledges funding support from a Wellcome Trust Senior Research Fellowship (223164/Z/21/Z), and MC_PC_20029, Sepsis Research (Fiona Elizabeth Agnew Trust), a BBSRC Institute Strategic Programme Grant to the Roslin Institute (BB/P013732/1, BB/P013759/1), and the Intensive Care Society of the United Kingdom. We acknowledge the support of Baillie Gifford and the Baillie Gifford Science Pandemic Hub at the University of Edinburgh. Parts of this research has been conducted using the UK Biobank Resource under project 788 and we would like to acknowledge the assistance of A.Tenesa in making this possible. Additional replication was also conducted using the UK Biobank Resource (Project 26041). This research was also funded by the National Institute for Health and Care Research (CO-CIN-01) and jointly by NIHR and UK Research and Innovation (CV220-169, MC_PC_19059). The views expressed in this article are those of the author(s) and not necessarily those of UKRI, the NIHR, or the Department of Health and Social Care. We also acknowledge the support of NHS Research Scotland (NRS) Greater Glasgow and Clyde Biorepository team. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
dc.languageeng
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshChild *
dc.subject.meshHumans *
dc.subject.meshAcute Disease *
dc.subject.meshAdenovirus Infections, Human*
dc.subject.meshAlleles *
dc.subject.meshCase-Control Studies *
dc.subject.meshCD4-Positive T-Lymphocytes *
dc.subject.meshCoinfection *
dc.subject.meshDependovirus *
dc.subject.meshGenetic Predisposition to Disease *
dc.subject.meshHelper Viruses *
dc.subject.meshHepatitis *
dc.subject.meshHepatocytes *
dc.subject.meshHLA-DRB1 Chains *
dc.subject.meshLiver *
dc.titleAdeno-associated virus 2 infection in children with non-A-E hepatitis
dc.typeArtigo
dc.authorsophosHo, A.; Orton, R.; Tayler, R.; Asamaphan, P.; Herder, V.; Davis, C.; Tong, L.; Smollett, K.; Manali, M.; Allan, J.; Rawlik, K.; McDonald, S.E.; Vink, E.; Pollock, L.; Gannon, L.; Evans, C.; McMenamin, J.; Roy, K.; Marsh, K.; Divala, T.; Holden, M.T.G.; Lockhart, M.; Yirrell, D.; Currie, S.; O'Leary, M.; Henderson, D.; Shepherd, S.J.; Jackson, C.; Gunson, R.; MacLean, A.; McInnes, N.; Bradley-Stewart, A.; Battle, R.; Hollenbach, J.A.; Henderson, P.; Odam, M.; Chikowore, P.; Oosthuyzen, W.; Chand, M.; Hamilton, M.S.; Estrada-Rivadeneyra, D.; Levin, M.; Avramidis, N.; Pairo-Castineira, E.; Vitart, V.; Wilkie, C.; Cunnington, A.; Herberg, J.; Kaforou, M.; Wright, V.; Bellos, E.; Broderick, C.; Channon-Wells, S.; Cooray, S.; De, T.; D'Souza, G.; Elorrieta, L.E.; Galassini, R.; Habgood-Coote, D.; Jackson, H.; Kavanagh, J.; Marjaneh, M.M.; Menikou, S.; Nichols, S.; Nijman, R.; Patel, H.; Pennisi, I.; Powell, O.; Reid, R.; Shah, P.; Vito, O.; Whittaker, E.; Wilson, C.; Womersley, R.; Abdulla, A.; Darnell, S.; Mustafa, S.; Georgiou, P.; Manzano, J.-R.; Moser, N.; Carter, M.; Tibby, S.; Cohen, J.; Davis, F.; Kenny, J.; Wellman, P.; White, M.; Fish, M.; Jennings, A.; Shankar-Hari, M.; Fidler, K.; Agranoff, D.; Richmond, V.; Seal, M.; Faust, S.; Owen, D.; Ensom, R.; McKay, S.; Mondo, D.; Shaji, M.; Schranz, R.; Rughnani, P.; Anpananthar, A.; Liebeschuetz, S.; Riddell, A.; Khalid, N.; Malcolm, I.L.; Simagan, T.; Peters, M.; Bamford, A.; O'Neill, L.; Pathan, N.; Daubney, E.; White, D.; Heightman, M.; Eisen, S.; Segal, T.; Wellings, L.; Drysdale, S.B.; Branch, N.; Hamzah, L.; Jarman, H.; Nyirenda, M.; Capozzi, L.; Gardiner, E.; Moots, R.; Nasher, M.; Hanson, A.; Linforth, M.; O'Riordan, S.; Ellis, D.; Deep, A.; Caro, I.; Shackley, F.; Bellini, A.; Gormley, S.; Neshat, S.; Scholefield, B.J.; Robbins, C.; Winmill, H.; Paulus, S.C.; Pollard, A.J.; Anthony, M.; Hopton, S.; Miller, D.; Oliver, Z.; Beer, S.; Ward, B.; Shrestha, S.; Pollard, A.J.; Gurung, M.; Amatya, P.; Pokhrel, B.; Bijukchhe, S.M.; Lubinda, T.; Kelly, S.; O'Reilly, P.; Martinón-Torres, F.; Salas, A.; González, F.Á.; Bello, X.; Ben García, M.; Carnota, S.; Cebey-López, M.; Curras-Tuala, M.J.; Suárez, C.D.; Vicente, L.G.; Gómez-Carballa, A.; Rial, J.G.; Iglesias, P.L.; Martinón-Torres, N.; Sánchez, J.M.M.; Pérez, B.M.; Pardo-Seco, J.; Rodríguez, L.P.; Pischedda, S.; Vázquez, S.R.; Calle, I.R.; Rodríguez-Tenreiro, C.; Redondo-Collazo, L.; Ora, M.S.; Fernández, S.S.; Trasorras, C.S.; Iglesias, M.V.; Carrol, E.D.; Cocklin, E.; Khanijau, A.; Lenihan, R.; Lewis-Burke, N.; Newall, K.; Romaine, S.; Tsolia, M.; Eleftheriou, I.; Spyridis, N.; Tambouratzi, M.; Maritsi, D.; Marmarinos, A.; Xagorari, M.; Panagiota, L.; Aggelos, P.; Karolina, A.; Charalambos, G.; Markos, M.; Michalis, V.; Ioanna, S.; Emonts, M.; Lim, E.; Isaacs, J.; Bell, K.; Crulley, S.; Fabian, D.; Thomson, E.; Wallia, D.; Miller, C.; Bell, A.; van der Velden, F.J.S.; Shenton, G.; Price, A.; Treloar, O.; Thomas, D.; Rojo, P.; Epalza, C.; Villaverde, S.; Márquez, S.; Gijón, M.; Machín, F.; Cabello, L.; Hernández, I.; Gutiérrez, L.; Manzanares, Á.; Kuijpers, T.W.T.; van de Kuip, M.M.; van Furth, A.M.M.; van den Berg, J.M.M.; Biesbroek, G.; Verkuil, F.; van der Zee, C.C.W.; Pajkrt, D.; van Hensbroek, M.B.; Schonenberg, D.; Gruppen, M.; Nagelkerke, S.; Jansen, M.H.; Goetschalckx, I.; Romani, L.; De Luca, M.; Chiurchiù, S.; Di Giuseppe, M.; Vermont, C.L.; Moll, H.A.; Borensztajn, D.M.; Hagedoorn, N.N.; Tan, C.; Zachariasse, J.; students, M.; Dik, W.; Shen, C.-F.K.; Zavadska, D.; Laivacuma, S.; Rudzate, A.; Stoldere, D.; Barzdina, A.; Barzdina, E.; Madelane, M.; Gravele, D.; Svile, D.; Basmaci, R.; Lachaume, N.; Bories, P.; Tkhayat, R.B.; Chériaux, L.; Davoust, J.; Ong, K.-T.; Cotillon, M.; de Groc, T.; Le, S.; Vergnault, N.; Sée, H.; Cohen, L.; de Tugny, A.; Danekova, N.; Mommert-Tripon, M.; Brengel-Pesce, K.; Pokorn, M.; Kolnik, M.; Av?in, T.; Avramoska, T.; Bahovec, N.; Bogovi?, P.; Kitanovski, L.; Nahtigal, M.; Papst, L.; Srovin, T.P.; Strle, F.; Srp?i?, A.; Vincek, K.; van der Flier, M.; Tissing, W.J.E.; Wösten-van Asperen, R.M.; Vastert, S.J.; Vijlbrief, D.C.; Bont, L.J.; Wolfs, T.F.W.; Beudeker, C.R.; Agyeman, P.; Schlapbach, L.; Aebi, C.; Usman, M.; Schlüchter, S.; Wyss, V.; Schöbi, N.; Zimmermann, E.; Meier, M.; Weber, K.; Agyeman, P.; Schlapbach, L.J.; Giannoni, E.; Stocker, M.; Posfay-Barbe, K.M.; Heininger, U.; Bernhard-Stirnemann, S.; Niederer-Loher, A.; Kahlert, C.; Natalucci, G.; Relly, C.; Riedel, T.; Aebi, C.; Berger, C.; Fink, C.; Voice, M.; Calvo-Bado, L.; Steele, M.; Holden, J.; Evans, B.; Stevens, J.; Matthews, P.; Billing, K.; Zenz, W.; Binder, A.; Kohlmaier, B.; Kohlfürst, D.S.; Schweintzger, N.A.; Zurl, C.; Hösele, S.; Leitner, M.; Pölz, L.; Rusu, A.; Rajic, G.; Stoiser, B.; Strempfl, M.; Sagmeister, M.G.; Bauchinger, S.; Benesch, M.; Ceolotto, A.; Eber, E.; Gallistl, S.; Haidl, H.; Hauer, A.; Hude, C.; Kapper, A.; Keldorfer, M.; Löffler, S.; Niedrist, T.; Pilch, H.; Pfleger, A.; Pfurtscheller, K.; Rödl, S.; Skrabl-Baumgartner, A.; Strenger, V.; Wallner, E.; Tempel, D.; van Keulen, D.; Strijbosch, A.M.; Tauchert, M.K.; von Both, U.; Kolberg, L.; Schmied, P.; Alba-Alejandre, I.; Danhauser, K.; Haas, N.; Hoffmann, F.; Griese, M.; Feuchtinger, T.; Juranek, S.; Kappler, M.; Lurz, E.; Maier, E.; Reiter, K.; Schoen, C.; Schroepf, S.; Yeung, S.; Dewez, M.; Bath, D.; Fitchett, E.; Cresswell, F.; Momodou, S.; Usuf, E.; Ndure, E.; Bojang, K.; Roca, A.; Sarr, I.; Semple, M.G.; Carson, G.; Openshaw, P.J.M.; Dunning, J.; Merson, L.; Russell, C.D.; Dorward, D.; Zambon, M.; Chand, M.; Tedder, R.S.; Khoo, S.; Turtle, L.C.W.; Solomon, T.; Ijaz, S.; Fletcher, T.; Thomson, E.C.; Price, N.; Breuer, J.; de Silva, T.; Donohue, C.; Hardwick, H.; Obosi, L.; Clohisey, S.; Law, A.; Norris, L.; Tait, S.; Wham, M.; Clark, R.; Coutts, A.; Donnelly, L.; Fawkes, A.; Gilchrist, T.; Hafezi, K.; MacGillivray, L.; Maclean, A.; McCafferty, S.; Morrice, K.; Murphy, L.; Wrobel, N.; Shaw, V.; Ahmed, K.A.; Armstrong, J.A.; Lett, L.; Henderson, P.; Pollock, L.; Kishore, S.; Brotherton, H.; Armstrong, L.; Mitra, A.; Dall, A.; Bohmova, K.; Logan, S.; Gannon, L.; Agwuh, K.; Chukkambotla, S.; DuRand, I.; Fullerton, D.; Gar, S.; Graham, C.; Grammatikopoulos, T.; Hartshorn, S.; Hodgson, L.; Jennings, P.; Koshy, G.; Leiner, T.; Limb, J.; Little, J.; Logan, S.; Matovu, E.; McGill, F.; Morris, C.; Morrice, J.; Price, D.; Reschreiter, H.; Reynolds, T.; Whittaker, P.; Jordan, T.; Tayler, R.; Irving, C.; Jack, K.; Ramsay, M.; Millar, M.; Milligan, B.; Hickey, N.; Connon, M.; Ward, C.; Beveridge, L.; MacFarlane, S.; Leitch, K.; Bell, C.; Finlayson, L.; Dawson, J.; Candlish, J.; McGenily, L.; Roome, T.; Diaba, C.; Player, J.; Powell, N.; Howman, R.; Burling, S.; Floyd, S.; Farmer, S.; Ferguson, S.; Hope, S.; Rubick, L.; Swingler, R.; Collins, E.; Spencer, C.; Jones, A.; Wilson, B.; Armstrong, D.; Birt, M.; Dickinson, H.; Harper, R.; Martin, D.; Roff, A.; Mills, S.; Palmarini, M.; Ray, S.; Robertson, D.L.; da Silva Filipe, A.; Willett, B.J.; Breuer, J.; Semple, M.G.; Turner, D.; Baillie, J.K.; Thomson, E.C.
dc.identifier.doi10.1038/s41586-023-05948-2
dc.identifier.sophos64860188a219857f1d78b6f5
dc.issue.number7961
dc.journal.titleNature*
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.) - Complexo Hospitalario Universitario de Santiago::Pediatría
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.) - Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.) - Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)::Pediatría
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.) - Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)::Pediatría
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.) - Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
dc.organizationServizo Galego de Saúde::Áreas Sanitarias (A.S.) - Complexo Hospitalario Universitario de Santiago::Pediatría
dc.page.initial555
dc.page.final563
dc.relation.projectIDPublic Health Scotland
dc.relation.projectIDNational Institute for Health Research (NIHR) [CO-CIN-01]
dc.relation.projectIDMedical Research Council (MRC) [MR/X010252/1, MC_UU_1201412, MC_UU_12018/12, MC_PC_19059, MC_PC_19025, MC_PC_22004]
dc.relation.projectIDEuropean Union [848196]
dc.relation.projectIDWellcome Trust [206369/Z/17/Z]
dc.relation.projectIDNIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool
dc.relation.projectIDUK Health Security Agency
dc.relation.projectIDWellcome Trust Senior Research Fellowship [223164/Z/21/Z, MC_PC_20029]
dc.relation.projectIDBBSRC Institute Strategic Programme Grant [BB/P013732/1, BB/P013759/1]
dc.relation.projectIDIntensive Care Society of the United Kingdom
dc.relation.projectIDPandemic Institute, Liverpool and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool
dc.relation.projectIDUniversity of Edinburgh
dc.relation.projectIDUK Biobank Resource [788, 26041]
dc.relation.projectIDNational Institute for Health and Care Research [CO-CIN-01]
dc.relation.projectIDNIHR [MC_PC_19059, CV220-169]
dc.relation.projectIDUK Research and Innovation [MC_PC_19059, CV220-169]
dc.relation.projectIDNHS Research Scotland (NRS)
dc.relation.projectIDMedical Research Council [MC_UU_12014/1, MC_PC_19059, MC_UU_12014/12, MC_UU_00007/10] Funding Source: researchfish
dc.relation.projectIDNational Institute for Health Research [NIHR200224] Funding Source: researchfish
dc.relation.projectIDCOVID [MR/W005611/1, MC_PC_19025, MC_PC_19059] Funding Source: UKRI
dc.relation.projectIDMRC [MC_UU_12014/1, MC_PC_22004, MR/W030454/1, MC_UU_00007/10, MC_UU_00034/5, MC_UU_00034/6, MR/X010252/1] Funding Source: UKRI
dc.relation.publisherversionhttps://doi.org/10.1038/s41586-023-05948-2
dc.rights.accessRightsopenAccess*
dc.subject.keywordAS Santiago
dc.subject.keywordCHUS
dc.subject.keywordAS Santiago
dc.subject.keywordIDIS
dc.subject.keywordAS Santiago
dc.subject.keywordIDIS
dc.subject.keywordAS Santiago
dc.subject.keywordIDIS
dc.subject.keywordAS Santiago
dc.subject.keywordIDIS
dc.subject.keywordAS Santiago
dc.subject.keywordCHUS
dc.typefidesArtículo Científico (incluye Original, Original breve, Revisión Sistemática y Meta-análisis)
dc.typesophosArtículo Original
dc.volume.number617


Ficheiros no ítem

Este ítem aparece na(s) seguinte(s) colección(s)

Mostrar o rexistro simple do ítem

Attribution 4.0 International (CC BY 4.0)
A non ser que se indique outra cousa, a licenza do ítem descríbese comoAttribution 4.0 International (CC BY 4.0)