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The Obestatin/GPR39 System Is Up-regulated by Muscle Injury and Functions as an Autocrine Regenerative System

dc.contributor.authorGurriarán Rodríguez, Uxía
dc.contributor.authorSantos Zas, Icía
dc.contributor.authorAL-MASSADI IGLESIAS, OMAR 
dc.contributor.authorSeoane Mosteiro, Carlos 
dc.contributor.authorBeiroa Tarrío, Daniel
dc.contributor.authorNogueiras Pozo, Rubén
dc.contributor.authorCrujeiras Martínez, Ana Belén
dc.contributor.authorSeoane Camino, Luisa Maria 
dc.contributor.authorSeñaris Rodriguez, Jose 
dc.contributor.authorGarcía-Caballero, Tomás 
dc.contributor.authorGallego, Rosalia
dc.contributor.authorCasanueva Freijo, Felipe 
dc.contributor.authorPazos Randulfe, Yolanda 
dc.contributor.authorPérez Camiña, Jesús 
dc.date.accessioned2017-06-07T07:05:49Z
dc.date.available2017-06-07T07:05:49Z
dc.date.issued2012
dc.identifier.issn0021-9258
dc.identifier.urihttp://hdl.handle.net/20.500.11940/2519
dc.description.abstractBackground: Satellite cell activation is orchestrated by several signals, which induce their differentiation into skeletal muscle fibers. Results: Obestatin and the GPR39 receptor exert an autocrine role on the control of myogenesis. Conclusion: Our data indicate that obestatin/GPR39 is an injury-regulated signal that functions as a myogenic regenerative system. Significance: Strategies to enhance obestatin-mediated signaling could be useful in treating trauma-induced muscle injuries and skeletal muscle myopathies.
dc.language.isoeng
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleThe Obestatin/GPR39 System Is Up-regulated by Muscle Injury and Functions as an Autocrine Regenerative System
dc.typeArtigoes
dc.authorsophosGurriaran-Rodriguez, Uxia
dc.authorsophosSantos-Zas, Icia
dc.authorsophosAl-Massadi, Omar
dc.authorsophosMosteiro, Carlos S.
dc.authorsophosBeiroa, Daniel
dc.authorsophosNogueiras, Ruben
dc.authorsophosCrujeiras, Ana B.
dc.authorsophosSeoane, Luisa M.
dc.authorsophosSenaris, Jose
dc.authorsophosGarcia-Caballero, Tomas
dc.authorsophosGallego, Rosalia
dc.authorsophosCasanueva, Felipe F.
dc.authorsophosPazos, Yolanda
dc.authorsophosCamina, Jesus P.
dc.identifier.doi10.1074/jbc.M112.374926
dc.identifier.isi310642200070
dc.identifier.sophos8901
dc.issue.number45
dc.journal.titleJOURNAL OF BIOLOGICAL CHEMISTRY
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Endocrinoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago - Complexo Hospitalario Universitario de Santiago::Traumatoloxía
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.relation.publisherversionhttp://www.jbc.org/content/287/45/38379.full.pdfes
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number287


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J Biol Chem. 2012;287(45):38379-89.

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