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Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers-the shanghai bladder cancer study
dc.contributor.author | Tao, L. | |
dc.contributor.author | Day, B. W. | |
dc.contributor.author | Hu, B. | |
dc.contributor.author | Xiang, Y. B. | |
dc.contributor.author | Wang, R. | |
dc.contributor.author | Stern, M. C. | |
dc.contributor.author | Gago Dominguez, Manuela | |
dc.contributor.author | Cortessis, V. K. | |
dc.contributor.author | Conti, D. V. | |
dc.contributor.author | Van Den Berg, D. | |
dc.contributor.author | Pike, M. C. | |
dc.contributor.author | Gao, Y. T. | |
dc.contributor.author | Yu, M. C. | |
dc.contributor.author | Yuan, J. M. | |
dc.date.accessioned | 2017-06-07T07:12:09Z | |
dc.date.available | 2017-06-07T07:12:09Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1055-9965 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/3767 | |
dc.description.abstract | BACKGROUND: 4-Aminobiphenyl (ABP) is an established human bladder carcinogen, with tobacco smoke being a major source of human exposure. Other arylamine compounds, including 2,6-dimethylaniline (2,6-DMA), have been implicated as possible human bladder carcinogens. Hemoglobin adducts of 4-ABP and 2,6-DMA are validated biomarkers of exposure to those compounds in humans. METHODS: The Shanghai Bladder Cancer Study enrolled 581 incident bladder cancer cases and 604 population controls. Each participant was solicited for his/her history of tobacco use and other lifestyle factors and donation of blood and urine specimens. Red blood cell lysates were used to quantify both hemoglobin adducts of 4-ABP and 2,6-DMA. Urine samples were used to quantify total cotinine. ORs and 95% confidence intervals (CI) for bladder cancer were estimated using unconditional logistic regression methods. RESULTS: Among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for low (below median of positive values) and high versus undetectable levels of 2,6-DMA hemoglobin adducts were 3.87 (1.39-10.75) and 6.90 (3.17-15.02), respectively (Ptrend < 0.001). Similarly, among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for third and fourth versus first/second quartiles of 4-ABP hemoglobin adducts was 1.30 (0.76-2.22) and 2.29 (1.23-4.24), respectively (Ptrend = 0.009). The two associations were independent of each other. CONCLUSION: Hemoglobin adducts of 4-ABP and 2,6-DMA were significantly and independently associated with increased bladder cancer risk among lifelong nonsmokers in Shanghai, China. IMPACT: The findings of the present study in China with previous data in Los Angeles, California strongly implicate arylamines as potential causal agents of human bladder cancer. | |
dc.language.iso | eng | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Aniline Compounds | |
dc.subject.mesh | Biomarkers, Tumor | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Female | |
dc.subject.mesh | Hemoglobins | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Smoking | |
dc.subject.mesh | Urinary Bladder Neoplasms | |
dc.title | Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers-the shanghai bladder cancer study | |
dc.type | Artigo | es |
dc.authorsophos | Tao, L. | |
dc.authorsophos | Day, B. W. | |
dc.authorsophos | Hu, B. | |
dc.authorsophos | Xiang, Y. B. | |
dc.authorsophos | Wang, R. | |
dc.authorsophos | Stern, M. C. | |
dc.authorsophos | Gago-Dominguez, M. | |
dc.authorsophos | Cortessis, V. K. | |
dc.authorsophos | Conti, D. V. | |
dc.authorsophos | Van Den Berg, D. | |
dc.authorsophos | Pike, M. C. | |
dc.authorsophos | Gao, Y. T. | |
dc.authorsophos | Yu, M. C. | |
dc.authorsophos | Yuan, J. M. | |
dc.identifier.doi | 10.1158/1055-9965.EPI-12-1447 | |
dc.identifier.isi | 318894200022 | |
dc.identifier.pmid | 23539508 | |
dc.identifier.sophos | 13567 | |
dc.issue.number | 5 | |
dc.journal.title | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago | |
dc.organization | Consellería de Sanidade::Fundación pública Galega de Medicina Xenómica | |
dc.page.initial | 937 | |
dc.page.final | 945 | |
dc.relation.publisherversion | https://cebp.aacrjournals.org/content/cebp/22/5/937.full.pdf | |
dc.rights.accessRights | openAccess | |
dc.typesophos | Artículo Original | |
dc.volume.number | 22 |