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dc.contributor.authorTao, L.
dc.contributor.authorDay, B. W.
dc.contributor.authorHu, B.
dc.contributor.authorXiang, Y. B.
dc.contributor.authorWang, R.
dc.contributor.authorStern, M. C.
dc.contributor.authorGago Dominguez, Manuela
dc.contributor.authorCortessis, V. K.
dc.contributor.authorConti, D. V.
dc.contributor.authorVan Den Berg, D.
dc.contributor.authorPike, M. C.
dc.contributor.authorGao, Y. T.
dc.contributor.authorYu, M. C.
dc.contributor.authorYuan, J. M.
dc.date.accessioned2017-06-07T07:12:09Z
dc.date.available2017-06-07T07:12:09Z
dc.date.issued2013
dc.identifier.issn1055-9965
dc.identifier.urihttp://hdl.handle.net/20.500.11940/3767
dc.description.abstractBACKGROUND: 4-Aminobiphenyl (ABP) is an established human bladder carcinogen, with tobacco smoke being a major source of human exposure. Other arylamine compounds, including 2,6-dimethylaniline (2,6-DMA), have been implicated as possible human bladder carcinogens. Hemoglobin adducts of 4-ABP and 2,6-DMA are validated biomarkers of exposure to those compounds in humans. METHODS: The Shanghai Bladder Cancer Study enrolled 581 incident bladder cancer cases and 604 population controls. Each participant was solicited for his/her history of tobacco use and other lifestyle factors and donation of blood and urine specimens. Red blood cell lysates were used to quantify both hemoglobin adducts of 4-ABP and 2,6-DMA. Urine samples were used to quantify total cotinine. ORs and 95% confidence intervals (CI) for bladder cancer were estimated using unconditional logistic regression methods. RESULTS: Among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for low (below median of positive values) and high versus undetectable levels of 2,6-DMA hemoglobin adducts were 3.87 (1.39-10.75) and 6.90 (3.17-15.02), respectively (Ptrend < 0.001). Similarly, among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for third and fourth versus first/second quartiles of 4-ABP hemoglobin adducts was 1.30 (0.76-2.22) and 2.29 (1.23-4.24), respectively (Ptrend = 0.009). The two associations were independent of each other. CONCLUSION: Hemoglobin adducts of 4-ABP and 2,6-DMA were significantly and independently associated with increased bladder cancer risk among lifelong nonsmokers in Shanghai, China. IMPACT: The findings of the present study in China with previous data in Los Angeles, California strongly implicate arylamines as potential causal agents of human bladder cancer.
dc.language.isoeng
dc.subject.meshAged
dc.subject.meshAniline Compounds
dc.subject.meshBiomarkers, Tumor
dc.subject.meshCase-Control Studies
dc.subject.meshFemale
dc.subject.meshHemoglobins
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRisk Factors
dc.subject.meshSmoking
dc.subject.meshUrinary Bladder Neoplasms
dc.titleElevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers-the shanghai bladder cancer study
dc.typeArtigoes
dc.authorsophosTao, L.
dc.authorsophosDay, B. W.
dc.authorsophosHu, B.
dc.authorsophosXiang, Y. B.
dc.authorsophosWang, R.
dc.authorsophosStern, M. C.
dc.authorsophosGago-Dominguez, M.
dc.authorsophosCortessis, V. K.
dc.authorsophosConti, D. V.
dc.authorsophosVan Den Berg, D.
dc.authorsophosPike, M. C.
dc.authorsophosGao, Y. T.
dc.authorsophosYu, M. C.
dc.authorsophosYuan, J. M.
dc.identifier.doi10.1158/1055-9965.EPI-12-1447
dc.identifier.isi318894200022
dc.identifier.pmid23539508
dc.identifier.sophos13567
dc.issue.number5
dc.journal.titleCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
dc.organizationServizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago
dc.organizationConsellería de Sanidade::Fundación pública Galega de Medicina Xenómica
dc.page.initial937
dc.page.final945
dc.relation.publisherversionhttps://cebp.aacrjournals.org/content/cebp/22/5/937.full.pdf
dc.rights.accessRightsopenAccess
dc.typesophosArtículo Original
dc.volume.number22


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