Cyclodextrin-polysaccharide-based, in situ-gelled system for ocular antifungal delivery

Lamas Díaz, María Jesús; Fernández Ferreiro, Anxo; Fernández Bargiela, Noelia; Santiago Varela, Maria; Gil Martinez, Maria; Pardo Pérez, María; Piñeiro Ces, Antonio; Blanco Méndez, José; González Barcia, Miguel; Lamas Díaz, María Jesús; Otero-Espinar, Francisco J.
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Estatísticas
Estatísticas
Identificadores
Identificadores
URI: http://hdl.handle.net/20.500.11940/4593
PMID: 25550757
ISSN: 1860-5397
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Data de publicación
2014
Título da revista
Beilstein Journal of Organic Chemistry
Tipo de contido
Artigo
DeCS
Ciclodextrinas | Fluconazol | 2-Hidroxipropil-beta-Ciclodextrina
MeSH
Cyclodextrins | Fluconazole | 2-hydroxypropyl-β-cyclodextrin
Resumo
Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole-HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.
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