Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Orr, N.; Lemnrau, A.; Cooke, R.; Fletcher, O.; Tomczyk, K.; Jones, M.; Johnson, N.; Lord, C. J.; Mitsopoulos, C; Zvelebil, M.; McDade, S. S.; Buck, G.; Blancher, C.; Trainer, A. H.; James, P. A.; Bojesen, S. E.; Bokm, , S.; Nevanlinna, H.; Mattson, J.; Friedman, E; Laitman, Y.; Palli, D.; Masala, G.; Zanna, I.; Ottini, L.; Giannini, G.; Hollestelle, A.; Van Den Ouwel, , A. M. W.; Novaković, S.; Krajc, M.; Gago Dominguez, Manuela; Castelao Fernández, José Esteban; Olsson, H.; Hedenfalk, I.; Easton, D. F.; Pharoah, P. D. P.; Dunning, A. M.; Bishop, D. T.; Neuhausen, S. L.; Steele, L.; Houlston, R. S.; Garcia-Closas, M.; Ashworth, A.; Swerdlow, A. J.
Thumbnail
Statistics
Statistics
Identifiers
Identifiers
URI: http://hdl.handle.net/20.500.11940/571
PMID: 23001122
ISSN: 1061-4036
Full record
Services
Services
RISMendeleyLinksolver
Files view or download
Files view or download
Date issued
2012
Journal title
NATURE GENETICS
Type of content
Artigo
DeCS
Neoplasias de la Mama Masculina | DNA-Binding Proteins | Proteínas de Unión al ADN | Estudio de Asociación del Genoma Completo
MeSH
Breast Neoplasms, Male | Chromosomes, Human, Pair 14 | DNA-Binding Proteins | European Continental Ancestry Group | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Male | Polymorphism, Single Nucleotide | Risk Factors
Abstract
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10-13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10-15; OR = 1.50).