Genome-wide association study identifies multiple loci associated with bladder cancer risk
Figueroa, JD; Ye, Y; Siddiq, A; Garcia-Closas, M; Chatterjee, N; Prokunina-Olsson, L; Cortessis, VK; Kooperberg, C; Cussenot, O; Benhamou, S; Prescott, J; Porru, S; Dinney, CP; Malats, N; Baris, D; Purdue, M; Jacobs, EJ; Albanes, D; Wang, Z; Deng, X; Chung, CC; Tang, W; Bueno-De-Mesquita, HB; Trichopoulos, D; Ljungberg, B; Clavel-Chapelon, F; Weiderpass, E; Krogh, V; Dorronsoro, M; Travis, R; Tjonneland, A; Brenan, P; Chang-Claude, J; Riboli, E; Conti, D; Gago Dominguez, Manuela; Stern, MC; Pike, MC; Van den Berg, D; Yuan, JM; Hohensee, C; Rodabough, R; Cancel-Tassin, G; Roupret, M; Comperat, E; Chen, C; De Vivo, I; Giovannucci, E; Hunter, DJ; Kraft, P; Lindstrom, S; Carta, A; Pavanello, S; Arici, C; Mastrangelo, G; Kamat, AM; Lerner, SP; Grossman, HB; Lin, J; Gu, J; Pu, X; Hutchinson, A; Burdette, L; Wheeler, W; Kogevinas, M; Tardon, A; Serra, C; Carrato, A; Garcia-Closas, R; Lloreta, J; Schwenn, M; Karagas, MR; Johnson, A; Schned, A; Armenti, KR; Hosain, GM; Andriole, G; Grubb, R; Black, A; Diver, WR; Gapstur, SM; Weinstein, SJ; Virtamo, J; Haiman, CA; Landi, MT; Caporaso, N; Fraumeni, JF; Vineis, P; Wu, X; Silverman, DT; Chanock, S; Rothman, N
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Identificadores
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Fecha de publicación
2014Título de revista
HUMAN MOLECULAR GENETICS
Tipo de contenido
Artigo
MeSH
Case-Control Studies | Genetic Loci | Genetic Predisposition to Disease | Genome-Wide Association Study | Genotype | Humans | Linkage Disequilibrium | Meta-Analysis as Topic | Polymorphism, Single Nucleotide | Risk | Urinary Bladder NeoplasmsResumen
Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 x 10(-5) was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 x 10(-9)) and rs907611 on 11p15.5 (P = 4.11 x 10(-8)). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 x 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 x 10(-7)); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.
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