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Genome-wide association study identifies multiple loci associated with bladder cancer risk
dc.contributor.author | Figueroa, JD | |
dc.contributor.author | Ye, Y | |
dc.contributor.author | Siddiq, A | |
dc.contributor.author | Garcia-Closas, M | |
dc.contributor.author | Chatterjee, N | |
dc.contributor.author | Prokunina-Olsson, L | |
dc.contributor.author | Cortessis, VK | |
dc.contributor.author | Kooperberg, C | |
dc.contributor.author | Cussenot, O | |
dc.contributor.author | Benhamou, S | |
dc.contributor.author | Prescott, J | |
dc.contributor.author | Porru, S | |
dc.contributor.author | Dinney, CP | |
dc.contributor.author | Malats, N | |
dc.contributor.author | Baris, D | |
dc.contributor.author | Purdue, M | |
dc.contributor.author | Jacobs, EJ | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Wang, Z | |
dc.contributor.author | Deng, X | |
dc.contributor.author | Chung, CC | |
dc.contributor.author | Tang, W | |
dc.contributor.author | Bueno-De-Mesquita, HB | |
dc.contributor.author | Trichopoulos, D | |
dc.contributor.author | Ljungberg, B | |
dc.contributor.author | Clavel-Chapelon, F | |
dc.contributor.author | Weiderpass, E | |
dc.contributor.author | Krogh, V | |
dc.contributor.author | Dorronsoro, M | |
dc.contributor.author | Travis, R | |
dc.contributor.author | Tjonneland, A | |
dc.contributor.author | Brenan, P | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Riboli, E | |
dc.contributor.author | Conti, D | |
dc.contributor.author | Gago Dominguez, Manuela | |
dc.contributor.author | Stern, MC | |
dc.contributor.author | Pike, MC | |
dc.contributor.author | Van den Berg, D | |
dc.contributor.author | Yuan, JM | |
dc.contributor.author | Hohensee, C | |
dc.contributor.author | Rodabough, R | |
dc.contributor.author | Cancel-Tassin, G | |
dc.contributor.author | Roupret, M | |
dc.contributor.author | Comperat, E | |
dc.contributor.author | Chen, C | |
dc.contributor.author | De Vivo, I | |
dc.contributor.author | Giovannucci, E | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Lindstrom, S | |
dc.contributor.author | Carta, A | |
dc.contributor.author | Pavanello, S | |
dc.contributor.author | Arici, C | |
dc.contributor.author | Mastrangelo, G | |
dc.contributor.author | Kamat, AM | |
dc.contributor.author | Lerner, SP | |
dc.contributor.author | Grossman, HB | |
dc.contributor.author | Lin, J | |
dc.contributor.author | Gu, J | |
dc.contributor.author | Pu, X | |
dc.contributor.author | Hutchinson, A | |
dc.contributor.author | Burdette, L | |
dc.contributor.author | Wheeler, W | |
dc.contributor.author | Kogevinas, M | |
dc.contributor.author | Tardon, A | |
dc.contributor.author | Serra, C | |
dc.contributor.author | Carrato, A | |
dc.contributor.author | Garcia-Closas, R | |
dc.contributor.author | Lloreta, J | |
dc.contributor.author | Schwenn, M | |
dc.contributor.author | Karagas, MR | |
dc.contributor.author | Johnson, A | |
dc.contributor.author | Schned, A | |
dc.contributor.author | Armenti, KR | |
dc.contributor.author | Hosain, GM | |
dc.contributor.author | Andriole, G | |
dc.contributor.author | Grubb, R | |
dc.contributor.author | Black, A | |
dc.contributor.author | Diver, WR | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | Weinstein, SJ | |
dc.contributor.author | Virtamo, J | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Landi, MT | |
dc.contributor.author | Caporaso, N | |
dc.contributor.author | Fraumeni, JF | |
dc.contributor.author | Vineis, P | |
dc.contributor.author | Wu, X | |
dc.contributor.author | Silverman, DT | |
dc.contributor.author | Chanock, S | |
dc.contributor.author | Rothman, N | |
dc.date.accessioned | 2017-06-07T07:32:31Z | |
dc.date.available | 2017-06-07T07:32:31Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0964-6906 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11940/7713 | |
dc.description.abstract | Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 x 10(-5) was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 x 10(-9)) and rs907611 on 11p15.5 (P = 4.11 x 10(-8)). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 x 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 x 10(-7)); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis. | |
dc.language.iso | eng | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Genetic Loci | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Genome-Wide Association Study | |
dc.subject.mesh | Genotype | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Linkage Disequilibrium | |
dc.subject.mesh | Meta-Analysis as Topic | |
dc.subject.mesh | Polymorphism, Single Nucleotide | |
dc.subject.mesh | Risk | |
dc.subject.mesh | Urinary Bladder Neoplasms | |
dc.title | Genome-wide association study identifies multiple loci associated with bladder cancer risk | |
dc.type | Artigo | es |
dc.authorsophos | Figueroa, JD | |
dc.authorsophos | Ye, Y | |
dc.authorsophos | Siddiq, A | |
dc.authorsophos | Garcia-Closas, M | |
dc.authorsophos | Chatterjee, N | |
dc.authorsophos | Prokunina-Olsson, L | |
dc.authorsophos | Cortessis, VK | |
dc.authorsophos | Kooperberg, C | |
dc.authorsophos | Cussenot, O | |
dc.authorsophos | Benhamou, S | |
dc.authorsophos | Prescott, J | |
dc.authorsophos | Porru, S | |
dc.authorsophos | Dinney, CP | |
dc.authorsophos | Malats, N | |
dc.authorsophos | Baris, D | |
dc.authorsophos | Purdue, M | |
dc.authorsophos | Jacobs, EJ | |
dc.authorsophos | Albanes, D | |
dc.authorsophos | Wang, Z | |
dc.authorsophos | Deng, X | |
dc.authorsophos | Chung, CC | |
dc.authorsophos | Tang, W | |
dc.authorsophos | Bueno-De-Mesquita, HB | |
dc.authorsophos | Trichopoulos, D | |
dc.authorsophos | Ljungberg, B | |
dc.authorsophos | Clavel-Chapelon, F | |
dc.authorsophos | Weiderpass, E | |
dc.authorsophos | Krogh, V | |
dc.authorsophos | Dorronsoro, M | |
dc.authorsophos | Travis, R | |
dc.authorsophos | Tjonneland, A | |
dc.authorsophos | Brenan, P | |
dc.authorsophos | Chang-Claude, J | |
dc.authorsophos | Riboli, E | |
dc.authorsophos | Conti, D | |
dc.authorsophos | Gago-Dominguez, M | |
dc.authorsophos | Stern, MC | |
dc.authorsophos | Pike, MC | |
dc.authorsophos | Van den Berg, D | |
dc.authorsophos | Yuan, JM | |
dc.authorsophos | Hohensee, C | |
dc.authorsophos | Rodabough, R | |
dc.authorsophos | Cancel-Tassin, G | |
dc.authorsophos | Roupret, M | |
dc.authorsophos | Comperat, E | |
dc.authorsophos | Chen, C | |
dc.authorsophos | De Vivo, I | |
dc.authorsophos | Giovannucci, E | |
dc.authorsophos | Hunter, DJ | |
dc.authorsophos | Kraft, P | |
dc.authorsophos | Lindstrom, S | |
dc.authorsophos | Carta, A | |
dc.authorsophos | Pavanello, S | |
dc.authorsophos | Arici, C | |
dc.authorsophos | Mastrangelo, G | |
dc.authorsophos | Kamat, AM | |
dc.authorsophos | Lerner, SP | |
dc.authorsophos | Grossman, HB | |
dc.authorsophos | Lin, J | |
dc.authorsophos | Gu, J | |
dc.authorsophos | Pu, X | |
dc.authorsophos | Hutchinson, A | |
dc.authorsophos | Burdette, L | |
dc.authorsophos | Wheeler, W | |
dc.authorsophos | Kogevinas, M | |
dc.authorsophos | Tardon, A | |
dc.authorsophos | Serra, C | |
dc.authorsophos | Carrato, A | |
dc.authorsophos | Garcia-Closas, R | |
dc.authorsophos | Lloreta, J | |
dc.authorsophos | Schwenn, M | |
dc.authorsophos | Karagas, MR | |
dc.authorsophos | Johnson, A | |
dc.authorsophos | Schned, A | |
dc.authorsophos | Armenti, KR | |
dc.authorsophos | Hosain, GM | |
dc.authorsophos | Andriole, G | |
dc.authorsophos | Grubb, R | |
dc.authorsophos | Black, A | |
dc.authorsophos | Diver, WR | |
dc.authorsophos | Gapstur, SM | |
dc.authorsophos | Weinstein, SJ | |
dc.authorsophos | Virtamo, J | |
dc.authorsophos | Haiman, CA | |
dc.authorsophos | Landi, MT | |
dc.authorsophos | Caporaso, N | |
dc.authorsophos | Fraumeni, JF | |
dc.authorsophos | Vineis, P | |
dc.authorsophos | Wu, X | |
dc.authorsophos | Silverman, DT | |
dc.authorsophos | Chanock, S | |
dc.authorsophos | Rothman, N | |
dc.identifier.doi | 10.1093/hmg/ddt519 | |
dc.identifier.isi | 331815000022 | |
dc.identifier.pmid | 24163127 | |
dc.identifier.sophos | 16258 | |
dc.issue.number | 5 | |
dc.journal.title | HUMAN MOLECULAR GENETICS | |
dc.organization | Consellería de Sanidade::Fundación pública Galega de Medicina Xenómica | |
dc.organization | Servizo Galego de Saúde::Estrutura de Xestión Integrada (EOXI)::EOXI de Santiago::IDIS.- Instituto de investigaciones sanitarias de Santiago | |
dc.page.initial | 1387 | |
dc.page.final | 1398 | |
dc.rights.accessRights | openAccess | |
dc.typesophos | Artículo Original | |
dc.volume.number | 23 |
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